Isolation and properties of the products of the covalent hydration of 4H-imidazoles |
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Authors: | V S Kobrin L B Volodarskii L A Tikhonova Yu G Putsykin |
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Institution: | (1) Novosibirsk Institute of Organic Chemistry, Siberian Branch, Academy of Sciences of the USSR, USSR |
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Abstract: | The neutralization of 5-hydroxy-4,4-dimethyl-2-imidazolinium chlorides yields in the free state the products of the covalent hydration of the corresponding 4H-imidazoles — 5-hydroxy-4, 4-dimethyl-2-imidazolines. On being heated, the compounds obtained undergo various transformations, depending on the presence and position of oxygen-containing functions: 5-hydroxy-2-imidazoline gives 2-acetylamino-2-methyl-1-phenylpropan-1-ol; 3,5-dihydroxy-2-imidazoline dehydrates to 4H-imidazole 3-oxide; and 1,5-dihydroxy-2-imidazolines are converted into 2,3-dihydro-4H-1,2,5-oxadiazines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1087–1092, August, 1973. |
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