Synthesis of functional 2-substituted 4-phenyl-9H-pyrimido[4,5-b]indoles |
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Authors: | Borovik V P Shkurko O P |
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Institution: | (1) Siberian Branch of the Russian Academy of Sciences, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 9 prosp. Akad. Lavrent"eva, 630090 Novosibirsk, Russian Federation |
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Abstract: | A method was developed for the synthesis of 2-oxo-4-phenyl-2,3-dihydro-9H-pyrimido4,5-b]indole as well as of 2-chloro- and 2-nitramino-4-phenylpyrimido4,5-b]indoles. The replacement of the chlorine atom in 2-chloropyrimidoindole gave rise to a number of its functional derivatives (morpholino, azido, and cyano). The reaction of 2-chloro-substituted pyrimidoindole with hydrazine hydrate and catalytic hydrogenation of 2-nitraminopyrimidoindole were studied. |
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Keywords: | 2-oxo-4-phenyl-2 3-dihydro-9H-pyrimido[4 5-b]indole 2-substituted 4-phenyl-9H-pyrimido[4 5-b]indoles diazotization nucleophilic substitution catalytic hydrogenation |
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