Multi-residue analysis of traces of pesticides and antibiotics in honey by HPLC-MS-MS |
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Authors: | Delphine Debayle Guy Dessalces Marie Florence Grenier-Loustalot |
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Institution: | (1) Service Central d’Analyse du CNRS, Echangeur de Solaize, BP 22, 69390 Vernaison, France |
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Abstract: | The aim of this work was to develop an analytical method for simultaneous assay of residues of two families of antibiotics,
and three pesticides, in honey. The assays involved a mixture of five tetracyclines, four sulfamides, and the pesticides coumaphos,
carbendazim, and amitraz (two metabolites). All the compounds were extracted from honey and pre-concentrated by optimised
solid-phase extraction (SPE). Analysis was by high-performance liquid chromatography-mass spectrometry-mass spectrometry (HPLC-MS-MS)
using a triple-quadrupole spectrometer in multiple reaction monitoring (MRM) mode in order to identify and quantify the compounds
present (Sheth et al J Agric Food Chem 38:1125–1130, 1990). During development of the analytical method a strong matrix effect
was found that depended on the floral origin of the honey. This led to the development of a standard additions method to quantify
the contaminants sought. |
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Keywords: | Honey Antibiotics Pesticides Multi-residues HPLC-MS-MS Solid-phase extraction |
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