A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336 |
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| Authors: | Fei-Xue Yu Yao Chen Yin-He Yang Guo-Hong Li |
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| Institution: | 1. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, China;2. Faculty of medicine, Kunming University of Science and Technology, Kunming, China;3. Faculty of medicine, Kunming University of Science and Technology, Kunming, China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China |
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| Abstract: | A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 μg/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.6–27.1 nM against cell lines HeLa, SGC-7901 and A549. |
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| Keywords: | Chaetomium sp M336 chemical constituents structure identification 6-Formamide-chetomin cytotoxicity antibacterial activities |
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