Synthesis of functionalized 4H-Chromenes catalyzed by lipase immobilized on magnetic nanoparticles |
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| Authors: | Weian Zhang Peng Chen Ziyuan Zhao Lei Wang Shujin Wang Ying Tang |
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| Affiliation: | 1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, People’s Republic of China;2. The Second Hospital of Jilin University, Changchun, People’s Republic of China;3. College of Food Science and Engineering, Jilin University, Changchun, People’s Republic of China |
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| Abstract: | In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5-triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via a multicomponent reaction firstly. Under the optimized reaction conditions, immobilized MML displayed high catalytic performance (Yield: 81–96%) and excellent reusability, indicating a high potential for practical operation. |
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| Keywords: | Lipase multicomponent magnetic nanoparticle immobilization 4H-chromene |
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