Preparation of stimuli-responsive nanogels based on poly(N,N-diethylaminoethyl methacrylate) by a simple “surfactant-free” methodology |
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| Authors: | Lizbeth A Manzanares-Guevara Francisco Paraguay-Delgado |
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| Institution: | 1. Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, B. C. Mexico, C.P. 22000;2. Centro de Investigación en Materiales Avanzados (CIMAV), Miguel de Cervantes 120, Complejo Industrial Chihuahua, Chihuahua, Chih, Mexico, C.P. 31136 |
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| Abstract: | The synthesis of poly(N,N-diethylaminoethyl methacrylate)-core-polyethyleneglycol-shell (PDEAEM-core-PEG-shell) nanogels was achieved by using a “surfactant-free” emulsion polymerization with the aid of commercially available polyethyleneglycol methyl ether methacrylates (PEGMAs) as polymerizable stabilizers. By adjusting the synthetic parameters like the choice of initiator, cross-linker, PEGMA:DEAEM ratio, and molecular weight of PEGMA, a series of core-shell nanogels varying in size (50–350 nm), PDEAEM content, and pH/temperature responsive behavior were obtained in reactions taking only 60 min. The nanogels were used as nanoreactors for the preparation of gold nanoparticles. The PEGylated nanogels have a great potential to be used for diagnosis and therapy. |
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| Keywords: | Environment sensitive polymers gold nanoparticles nanogels polyethyleneglycol surfactant free emulsion |
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