Sonochemical synthesis of methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones using SnII-montmorillonite |
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Authors: | Majid Ahmadzadeh Zohre Zarnegar |
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Affiliation: | Laboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry and Biochemistry, University of Kashan, Kashan, Iran |
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Abstract: | Tin exchanged montmorillonite K10 (SnII-Mont K10) was prepared by ion exchange between SnCl2 and montmorillonite K10. The SnII-Mont K10 was characterized by X-ray diffraction, scanning electron microscope and energy-dispersive X-ray spectroscopy. The synthesized SnII-Mont K10 was used as a recoverable solid catalyst for synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones via one-pot multicomponent cyclocondensation of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives in water under ultrasound irradiations. The yields of products were obtained 87–96%. The remarkable advantages of this method are a low-cost and eco-friendliness catalyst, rapid completion of the reactions, and avoidance of using organic solvents, excellent yield and mild conditions. |
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Keywords: | Isoxazoles ultrasound irradiation montmorillonite K10 heterogeneous catalyst SnCl2 |
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