Study on the inclusion interaction of p-sulfonatocalix[n]arenes with norfloxacin |
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| Authors: | Jianbin Chao Kailun Song Huijuan Wang Zhiqiang Guo Bingtai Zhang Ting Zhang |
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| Affiliation: | 1. Scientific Instrument Center, Shanxi University, Taiyuan, P.R. Chinachao@sxu.edu.cn;3. Scientific Instrument Center, Shanxi University, Taiyuan, P.R. China;4. School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P.R. China;5. Second Clinical Hospital of Shanxi Medical University, Taiyuan, China |
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| Abstract: | The inclusion complexes of norfloxacin (NFX) with p-sulfonatocalix[n]arenes (SCXn) were studied. The characteristics of host–guest (HG) complexation between p-sulfonatocalix[n]arenes with NFX were investigated by fluorescence spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Stoichiometry and association constants (K) of the inclusion complexes were determined by the non-linear fitting method. An interesting 1:1 stochiometric of HG complexes were formed at different pH values (pH = 3.00, 6.00, 8.00) The inclusion mode of NFX with p-sulfonatocalix[n]arenes was confirmed by NMR spectroscopy. |
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| Keywords: | P-sulfonatocalix[n]arenes norfloxacin inclusion complexes fluorescence spectroscopy |
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