Coumarins and alkaloids from the roots of Toddalia asiatica |
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| Authors: | Sanwat Sukieum Wichien Sang-aroon |
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| Affiliation: | 1. Natural Products Research Unit, Faculty of Science, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand;2. Faculty of Engineering, Department of Chemistry, Rajamangala University of Technology Isan, Khon Kaen, Thailand |
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| Abstract: | The EtOAc and MeOH extracts of the roots of Toddalia asiatica Lam. were investigated for the roots’ chemical constituents. Two new compounds including 2′R-acetoxytoddanol (1) and 8S-10-O-demethylbocconoline (3) as well as 15 known compounds were isolated. Compound 10 showed strong cytotoxicity against KB cells with an IC50 value of 2.60 μg/mL, which is nearly equal to the ellipticine standard, but showed no activity against Vero cells. Alkaloid 3 displayed weak cytotoxicity against the KB cell line with an IC50 value of 21.69 μg/mL. |
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| Keywords: | Toddalia asiatica 2′R-Acetoxytoddanol quinolone alkaloid phenanthridine |
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