Efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by titanium silicon oxide nanopowder in aqueous media |
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| Authors: | Ramamohan Mekala M. V. Madhubabu G. Dhanunjaya Sridhar Regati K. B. Chandrasekhar Jayaprakash Sarva |
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| Affiliation: | 1. Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Hyderabad, Telangana, India;2. Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, Indiaramamohanm@drreddys.com;4. Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India |
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| Abstract: | An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives is accomplished in aqueous media by a three-component reaction of isatoic anhydride, primary amines or ammonium acetate, and aldehydes catalyzed by titanium silicon oxide nanopowder. A variety of 2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized using this methodology in good to excellent yields. The catalyst was recovered and recycled up to four times without significant loss in the catalytic activity. |
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| Keywords: | Green chemistry nanopowder nitrogen heterocycles quinazolinones reusable catalyst |
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