Investigation into Sonogashira reaction on 5-iodo-1-(phenyl/p-halophenyl)imidazole-4-carbonitrile compounds |
| |
Authors: | Aniruddha Das |
| |
Institution: | 1. University College of Science, Technology &2. Agriculture, University of Calcutta, Kolkata, Indiaaniruddha.1086@rediffmail.com |
| |
Abstract: | Investigation into Sonogashira reaction on 5-iodo-1-(phenyl/p-halophenyl)imidazole-4-carbonitrile compounds had been developed by introducing an iodo atom at the C-5 position of the imidazole ring of 5-amino-1-(phenyl/p-halophenyl)imidazole-4-carbonitrile compounds. Specifically, 5-iodo-1-(4-iodophenyl)imidazole-4-carbonitrile compound had shown double Sonogashira coupling reactions with two differently substituted iodine along with the formation of two other compounds where an unusual coupling product with self-aggregation property was obtained. In other cases, monocoupling had been observed together with another compound where iodine atom present at C5 position of imidazole was replaced by hydrogen atom. |
| |
Keywords: | 5-Iodo derivative of AICN double scope of Sonogashira reaction self-aggregation property unusual coupling |
|
|