New asymmetrical bispyrrolidinoindoline diketopiperazines from the marine fungus Aspergillus sp. DX4H |
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| Authors: | Jinzhong Xu Qian Hu Wanjing Ding Pinmei Wang |
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| Institution: | Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan, China |
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| Abstract: | Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1–3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey’s method. Their inhibitory activity against PC3 cell line had been tested. |
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| Keywords: | Bispyrrolidinoindoline diketopiperazine asymmetric Aspergillus identification cytotoxicity |
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