Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica |
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| Authors: | Chihiro Ito Makiko Takano Tian-Shung Wu Masataka Itoigawa |
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| Institution: | 1. Faculty of Pharmacy, Meijo University, Tempaku, Japan;2. Department of Chemistry, National Cheng Kung University, Tainan, Taiwan;3. School of Sport and Health Science, Tokai Gakuen University, Miyoshi, Japan |
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| Abstract: | Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2–9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC50 < 9.06 μM). This compound appeared to affect the cell cycle. |
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| Keywords: | Plumbago zeylanica Plumbaginaceae naphthoquinones cell proliferation cell cycle |
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