New natural barrigenol-like triterpenoid isolated from the husks of Xanthoceras sorbifolia Bunge |
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| Authors: | Da Wang Bin Yu Chuming Chen Jie Duan Donghua Di Xin Xiong |
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| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;3. Dalian American international school grade 11, Dalian, People’s Republic of China |
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| Abstract: | The Xanthoceras sorbifolia Bunge husks were known for their abundant triterpenoids resource, which contributed to many bioactivities, such as antitumor, antiinflammatory and neuroprotection. The present study has led to the purification of a new triterpenoid saponin, 21β-O-acetyl-xanthohuskiside A (1), together with six known barrigenol derivatives (2–7), whose structures were authenticated on the basis of NMR, HR-MS, IR spectrum and acid hydrolysis experiment. Compound 7 showed more noteworthy cytotoxicity towards three human tumour cell lines (HCT-116, HepG-2 and U87-MG) than other compounds. |
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| Keywords: | Xanthoceras sorbifolia Bunge 16-deoxybarringtogenol C carbohydrate chain cytotoxicity |
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