Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes |
| |
Authors: | Hong Xu Li Eunji Jo Chang-Seon Myung Young Ho Kim |
| |
Affiliation: | College of Pharmacy, Chungnam National University, Daejeon, Korea |
| |
Abstract: | In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8–9 and 17–18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation. |
| |
Keywords: | Morus alba L. Mulberry leaf Lipid accumulation Antiobesity |
|
|