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Efficient synthesis of functionalized olefins by Wittig reaction using Amberlite resin as a mild base
Authors:Tushar R. Valkute  Eswar K. Aratikatla
Affiliation:1. Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, Maharashtra, India;2. Academy of Scientific and Innovative Research, CSIR-National Chemical Laboratory, Pune, India
Abstract:A convenient procedure for the synthesis of olefins by the reaction of stabilized, semistabilized, and nonstabilized phosphorous ylides with various aldehydes or ketone using Amberlite resin as a mild base is described. Our developed method offers facile and racemization-free synthesis of α,β-unsaturated amino esters and chiral allylic amine. The developed methodology offers mild reaction conditions, high efficiency, and facile isolation of the final products, a practical alternative to known procedures.
Keywords:Aldehyde  alkene  Amberlite resin  phosphonium ylides  Wittig reaction
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