Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ |
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| Authors: | Jin Soo Kim Seul Gi Lee Young Jin Kang Taeg Kyu kwon |
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| Institution: | 1. Department of Food Science and Biotechnology, Kyungpook national University, Daegu, Korea;2. Department of Pharmacology, College of Medicine, Yeungnam University, Daegu, Korea;3. Department of Immunology, School of Medicine, Keimyung University, Daegu, Korea |
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| Abstract: | Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment. |
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| Keywords: | 3T3-L1 adipocytes anti-adipogenic Coffea arabica kahweol PPAR |
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