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A bio-oriented anthranilic acid catalyzed synthesis of quinazolin-8 (4H)-one derivatives: Evaluation by green chemistry metrics |
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| Authors: | Sunil Vibhute Dattatraya Jamale Santosh Undare Navanath Valekar Kirti Patil Govind Kolekar |
| Institution: | 1. Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Maharashtra, India;2. Department of Chemistry, Balbhim College of Arts, Science and Commerce, Beed, Beed, Maharashtra, India;3. Medicinal Chemistry Laboratory, Department of Chemistry, Shivaji University, Kolhapur, Maharashtra, India;4. Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, Maharashtra, India |
| Abstract: | An environmental friendly synthetic route has been investigated for the synthesis of quinazolin-8 (4H)-one derivatives in the presence of anthranilic acid as a catalyst. The zwitter ion formed in course of reaction may a play key role in the desired transformations leading good to excellent yields. Evaluation of the present protocol by green chemistry metrics demonstrated that it is highly efficient and eco-compatible. |
| Keywords: | 5-phenyl cyclohexane-1 3-dione anthranilic acid green chemistry metrics quinazolin-8 (4H)-one derivative zwitterions |