The role of chalcones: helichrysetin,xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells |
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| Authors: | Chia-Wei Phan Wai-Kuan Yong Sri Nurestri Abd Malek |
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| Affiliation: | 1. Faculty of Medicine, Department of Anatomy, University of Malaya, Kuala Lumpur, Malaysia;2. Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;3. Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;4. Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;5. Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia |
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| Abstract: | Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p < 0.05) percentage of neurite-bearing PC12 Adh cells and the highest (p < 0.05) NGF level in the culture medium of xanthohumol-treated cells. While, helichrysetin induced a moderately high numbers of neurite-bearing cells, flavokawin-C did not stimulate neurite outgrowth. This work supports the potential use of xanthohumol as a potential neuroactive compound to stimulate neurite outgrowth. |
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| Keywords: | Chalcone helichrysetin xanthohumol flavokawin-C PC12 neurite outgrowth |
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