Facile,eco-friendly,one-pot protocol for the synthesis of indole-imidazole derivatives catalyzed by amino acids |
| |
| Authors: | Sadia Naureen Fatima Ijaz Areesha Nazeer Faryal Chaudhry Munawar Ali Munawar Misbahul Ain Khan |
| |
| Affiliation: | 1. Institute of Chemistry, University of the Punjab, Lahore, Pakistanphdline123@yahoo.com;3. Institute of Chemistry, University of the Punjab, Lahore, Pakistan;4. Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan |
| |
| Abstract: | An efficient, convenient green approach for the synthesis of indole-based 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by multicomponent reaction of substituted 2-arylindole-3-carbaldehydes, benzil, substituted anilines, and ammonium acetate using catalytic amino acid (glycine) in ethanol is described. Several amino acids have also been evaluated as organic catalysts for these reactions. The structures of the compounds have been established on the basis of infrared, mass, and 1H NMR spectral data. The mild reaction conditions, inexpensive/economical reagents, and good yield show the usefulness of this approach. |
| |
| Keywords: | Indole aldehydes MCR tetraarylimidazoles triarylimidazoles |
|
|
