Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition,antioxidant and hypoglicaemic activities |
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| Authors: | M R Loizzo T Falco M Bonesi V Sicari R Tundis M Bruno |
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| Institution: | 1. Department of Pharmacy, Health Sciences and Nutrition, University of Calabria, Rende (CS), Italymonica_rosa.loizzo@unical.it;3. Department of Pharmacy, Health Sciences and Nutrition, University of Calabria, Rende (CS), Italy;4. Department of Agraria, University “Mediterranea” of Reggio Calabria, Reggio Calabria (RC), Italy;5. Department STEBICEF, University of Palermo, Palermo, Italy |
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| Abstract: | Ruta chalepensis L. (Rutaceae) leaf extract was investigated for its chemical profile and antioxidant and hypoglycaemic properties. The antioxidant effects were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and metal chelating activity assays. The carbohydrate-hydrolysing enzymes inhibition assay was used to test the hypoglycaemic potential. R. chalepensis showed a high content of hesperidin and rutin with values of 591.9 and 266.7 mg/g dry extract, respectively. The extract exhibited a promising protection of lipid peroxidation (IC50 value of 16.9 μg/mL) and inhibited both α-amylase and α-glucosidase enzymes in a concentration-dependent manner. The highest activity was found against α-amylase (IC50 value of 69.0 μg/mL). The obtained results support the use of R. chalepensis leaves as healthy food ingredients. |
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| Keywords: | Ruta chalepensis leaves HPLC analysis antioxidant activity hypoglycaemic activity |
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