Oxidatively rearranged cycloartane triterpenoids from the seeds of Pseudolarix amabilis |
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| Authors: | Hui Guo Shen Yao Xinyi Yang Yunfei Chen Yan Chen Feng Gong |
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| Institution: | College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. China |
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| Abstract: | One novel and eight known oxidatively rearranged cycloartane triterpenoids were isolated from the seeds of Pseudolarix amabilis. The structure of the new isolate was elucidated on extensive spectroscopic analyses. Results indicated that pseudolarolide Q (4) exhibited strong antimicrobial activity against Gram-positive Staphylococcus aureus and Candida albicans at the MICs of 6.08 and 24.32 μM, respectively. Pseudolarolide I (2) showed the 11β-HSD1 inhibitory property at the IC50 value of 34.5 nM. |
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| Keywords: | Pseudolarix amabilis cycloartane triterpenoids antibacterial activity |
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