Anti-steatosis compounds from leaves of Mallotus furetianus |
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| Authors: | Xuedan Huang Mingzhu Xu Tatsuya Shirahata Wei Li Kazuo Koike Akiko Kojima-Yuasa |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japankouse@pharm.kitasato-u.ac.jp;3. School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan;4. Faculty of Pharmaceutical Science, Toho University, Funabashi, Japan;5. Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan |
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| Abstract: | There is no drug administration-approved therapy for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, eight compounds, gallic acid (1), methyl gallate (2), corilagin (3), 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (4), repandinin B (5), (Z)-3-hexenyl-β-D-glucopyranoside (6), (+)-lyoniresinol-3α-O-α-L-rhamnopyranoside (7) and mallophenol A (8) were isolated from the active fractions of Mallotus furetianus. Three compounds, (6, 7 and 8) revealed potent anti-steatosis activity in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05 (6), 0.0005 (7) and 0.0005 (8) μg/mL, which were much lower than the control compound, fibrate (72.4 μg/mL). |
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| Keywords: | Mallotus furetianus anti-steatosis (Z)-3-hexenyl-β-D-glucopyranoside (+)-lyoniresinol-3α-O-α-L-rhamnopyranoside mallophenol A |
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