Reversible release of nitric oxide from an iron(II) nitrosyl complex containing a biomimetic S4N chelate. A facile release of nitric oxide |
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Authors: | Shaban Y Shaban |
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Institution: | Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh, Egypt |
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Abstract: | The release of NO by Fe(NO)(Et2NpyS4)], where (Et2NpyS4)2? = 2,6-bis(2-mercaptophenylthiomethyl)-4-substituted pyridine(2-), has been studied in the absence and presence of a trapping agent. The results show that Fe(NO)(Et2NpyS4)] releases NO spontaneously in solution with a slow rate, k-NO = 1.7 × 10?4 s?1 at 23 °C, in a reversible reaction. NO release becomes faster when the reaction intermediate Fe(Et2 NpyS4)] was trapped by CO, thereby preventing the back reaction. The release of NO was studied as a function of CO concentration and temperature. The reported activation parameters, especially the positive activation entropy values for the release of NO, favor the operation of a dissociative interchange (Id) mechanism. Thus, Fe(NO)(Et2NpyS4)] can serve as a NO deliverer. |
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Keywords: | Nitric oxide release reversible binding of NO kinetics iron-sulfur complexes |
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