Organoruthenium(II) compounds with pyridyl benzoxazole/benzthiazole moiety: studies on DNA/protein binding and enzyme mimetic activities |
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| Authors: | Asaithambi Gomathi Paranthaman Vijayan Shanmugam Suresh Raju Nandhakumar Takeshi Hashimoto |
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| Institution: | 1. Department of Chemistry, Periyar University, Salem, India;2. Department of Chemistry, Karunya University, Coimbatore, India;3. Faculty of Science and Technology, Department of Materials and Life Sciences, Sophia University, Tokyo, Japan |
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| Abstract: | We report herein synthesis and characterization of four new organoruthenium(II) complexes of the type RuH(CO)(PPh3)2(L1,2)]Cl (1, 3) and Ru(CO)(Cl)2(AsPh3)(L1,2)] (2, 4) derived from the reaction of RuHCl(CO)(EPh3)3] (E = P or As) with 2-(pyridine-2yl)benzoxazole (L1) and 2-(pyridine-2yl)benzthiazole (L2). Single-crystal X-ray diffraction data of 2 proved octahedral geometry of the complexes with a 1?:?1 ratio between the metal and the coordinated ligands. The binding affinities of 1–4 toward calf-thymus DNA (CT-DNA) and BSA were thoroughly studied by various spectroscopic techniques. Furthermore, the coordination compounds exhibit catecholase-like activities in the aerial oxidation of 3,5-di-tert-butylcatechol to the corresponding o-quinone and phosphatase-like activities in the hydrolysis of 4-nitrophenyl phosphate to 4-nitrophenolate ion. The kinetic parameters have been determined using Michaelis–Menten approach. The highest kcat values suggested that coordination compounds exhibit higher rates of catalytic efficacy. |
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| Keywords: | Ruthenium(II) compound X-ray structure DNA/BSA binding enzyme kinetic studies |
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