Synthesis and antimicrobial activities evaluation of some new thiadiazinone and thiadiazepinone derivatives bearing sulfonamide moiety |
| |
| Authors: | Hany M. M. Dalloul Khaled A. El-Nwairy Ali Z. Shorafa Ahmed S. Abu Samaha |
| |
| Affiliation: | 1. Department of Chemistry, Faculty of Applied Science, Alaqsa University of Gaza, Gaza, Gaza Strip, Palestinehmdalloul60@yahoo.com;3. Ministry of Education &4. Higher Education, Beirut street, Southern remal, Gaza, Gaza Strip, Palestine;5. Department of Biology, Faculty of Applied Science, Alaqsa University of Gaza, Gaza, Gaza Strip, Palestine |
| |
| Abstract: | A new series of novel functionalized 1,3,4-thiadiazin-5-ones and 1,3,4-thiadi-azepin-5-ones bearing sulfonamide moieties were synthesized via 1,3-dipolar cyclocondensation reaction of nitrilimines with α-mercaptoesters and mercaptosuccinic acid respectively. The structures of the prepared compounds were confirmed by spectral methods (IR, 1H-NMR, 13C-NMR and MS spectroscopy) and elemental analysis. The newly synthesized compounds were screened for their in vitro antimicrobial activity. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes. |
| |
| Keywords: | α-Mercaptoesters 1,3,4-Thiadiazinone 1,3,4-Thiadiazepinone nitrilimines Sulfa drugs Mercaptosuccinic acid |
|
|
