Synthesis of cyclopropa[c]indeno[1,2-b]quinolines through a MCR/Staudinger/aza-Wittig sequence |
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| Authors: | Bing-Jie Nie Li-Hui Wu Yang Sun Jing Wu |
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| Affiliation: | College of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, Hubei, China |
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| Abstract: | Spirocyclopropanes were prepared from aromatic aldehydes, 1,3-indandione and acetophenones through a halogenation/SN2-displacement/Michael-initiated ring-closing sequence by a pyridinium-ylide-assisted multicomponent reaction, and their further use was also researched in the construction of cyclopropa[c]indeno[1,2-b]quinolines through subsequent Staudinger/aza-Wittig reactions. |
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| Keywords: | Cyclopropa[c]indeno[1,2-b]quinolines multicomponent reaction spirocyclopropane Staudinger/aza-Wittig reaction |
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