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Two new linear acetogenins from the fruits of Goniothalamus gracilipes
Authors:Quy Hung Trieu  Marc Litaudon  Dao Phi Thi  Tuan Anh Tran  Van Hung Nguyen
Institution:1. Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam;2. Faculty of Natural Sciences, Hung Vuong University, Viettri, Vietnam;3. Département de Chimie des Substances Naturelles et Chimie Médicinale, Institut de Chimie des Substances Naturelles, Paris, France
Abstract:Two new linear acetogenins, gracilipin A (1) and methylsaccopetrin A (2) along with seven known compounds, saccopetrin A (3), 7,3′,4′-trimethylquercetin (4), rhamnazin (5), casticin (6), isokanugin (7), melisimplexin (8) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (9) were isolated from the fruits of Goniothalamus gracilipes Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds 1 and 3 showed cytotoxic activity against KB cell line with IC50 values of 14.6 and 15.3 μM, respectively.
Keywords:Annonaceae  Goniothalamus gracilipes  Gracilipin A  methyl-saccopetrin A  cytotoxic activity
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