Rauvolfianine,a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae) |
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| Authors: | Robert Ebeh Messanga Auguste Abouem A. Zintchem Mbabi Nyemeck II Norbert Moni Ndedi Esther Del Florence Betote Diboué Patrick Hervé |
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| Affiliation: | 1. Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon;2. Department of Chemistry, Higher Training College, University of Yaoundé I, Yaoundé, Cameroon;3. Faculty of Chemistry, Philipps-Universit?t Marburg, Marburg, Germany;4. Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon |
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| Abstract: | The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most active (MIC = 7.8125 and 31.25 μg/mL) towards the Isoniazid resistant strain of Mycobacterium tuberculosis AC45. Their structures and relative stereochemistry were elucidated by spectroscopic methods. |
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| Keywords: | Rauvolfia caffra Apocynaceae Rauvolfianine glycerol ester 1D and 2D NMR antitubercular activity |
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