An efficient synthesis of 2-Aminoethylidene-1,1-Bisphosphonates derivatives via Michael addition reaction |
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| Authors: | Mingxiu Lv Mengwei Wang Kui Lu Lu Peng Yufen Zhao |
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| Institution: | 1. School of Material and Chemical Engineering, Henan University of Engineering, Zhengzhou, Chinamingxiulv@163.com;3. School of Material and Chemical Engineering, Henan University of Engineering, Zhengzhou, China;4. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China;5. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China;6. Departmentl of Chemistry, Xiamen University, Xiamen, China |
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| Abstract: | A facile, rapid and cheap synthetic strategy towards a wide range of novel 2-aminoethylidene-1,1-bisphosphonate derivatives was developed through the Michael addition reaction of various aromatic amines, aromatic amides as well as nucleoside analogues with tetraethyl ethenylidene-1,1-bisphosphonate. All the newly obtained compounds were characterized by 1H, 31P, 13C NMR spectroscopy, IR and HR MS. |
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| Keywords: | Bisphosphonates aromatic amines and amides nucleoside analogues Michael addition reaction |
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