Synthesis,characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug flufenamic acid |
| |
Authors: | Gui-Hua Sheng Tian-Rui Wang Cun-Fang Wang Xiang-Fei Chen Zheng Ma Hai-Liang Zhu |
| |
Institution: | School of Life Sciences, Shandong University of Technology, ZiBo, PR China |
| |
Abstract: | CuII(L)2.C12H10N2] with flufenamic acid (HL=C14H10F3NO2) and phenanthroline (C12H10N2O) was synthesized and characterized by C, H and N elemental analysis, single-crystal X-ray diffraction and, IR spectra. The urease inhibitory and antibacterial activities of the complex were tested. The complex showed strong inhibitory activity against jack bean urease with an IC50 value of 0.265 μM. Four bacteria, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and proteusbacillus vulgaris, were used in the antibacterial test. The complex showed strong inhibitory activity against the species with IC50 values of 2.016, 35.037, 10.680, and 3.820 μM. The interactions of the complex with human serum albumin (HSA) were studied through fluorescence spectroscopy. By analyzing the experimental data, we concluded that the fluorescence quenching mechanism of the complex with serum albumin was static quenching. The binding mode of the complex with DNA through UV spectroscopy was electrostatic binding or groove. |
| |
Keywords: | Complex flufenamic acid urease inhibitors antibacterial HSA DNA |
|
|