A new12-membered lactone from the stems of Ficus auriculata |
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| Authors: | Tai-Ming Shao Cai-Juan Zheng Xiao-Bao Li Guang-Ying Chen |
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| Institution: | 1. Key Labortory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P. R. China;2. Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou, P. R. China |
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| Abstract: | A new lactone ficusine D (1), together with six known compounds (2–7) were isolated from the stems of the Ficus auriculata. The new compound 1 was a rare 12-membered lactone containing a quinone ring skeleton. The structure of the 1 was elucidated by comprehensive spectroscopic data. The relative and absolute configurations of 1 were elucidated by the ROESY analysis and biogenesis pathway. All compounds were evaluated for their antibacterial activities against six pathogenic bacteria in vitro. Compounds 6 and 7 exhibited potent antibacterial activities against Bacillus cereus with the MIC values of 2.5 and 5 μM, respectively. |
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| Keywords: | Ficus auriculata lactone antibacterial activity |
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