Xylastriasan A,a new cytochalasan from the fungus Xylaria striata |
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Authors: | Chuan-Wen Lei Zhi-Qin Yang Yan-Ping Zeng Yun Zhou Yi Huang Xin-Sheng He |
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Institution: | School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, P.R. China |
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Abstract: | Xylastriasan A (1), a new cytochalasan alkaloid with a rare 5/6/6/5/6 pentacyclic skeleton, and ergosterol (2) were isolated from the ethanol extract of fruiting bodies of the fungus Xylaria striata. Their structures were determined by analysis of their spectroscopic data. Compound 1 exhibited weak cytotoxic activity against HEPG2, B16 and A549 cell lines with IC50 values of 93.61, 85.61 and 91.58 μM, respectively. Ergosterol (2) potentiated pentobarbital-induced sleep by not only increasing the number of falling asleep and prolonging sleeping time but also reducing sleep latency at a dosage of 5 mg/kg. |
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Keywords: | Xylaria striata cytochalasan ergosterol cytotoxic hypnotic activity |
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