An isoindole alkaloid from Portulaca oleracea L. |
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| Authors: | Mingyue Jiang Wenjie Zhang Xu Yang Fen Xiu Haoran Xu |
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| Institution: | School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China |
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| Abstract: | A novel isoindole alkaloid named oleraisoindole (1), together with six known compounds, 7′-ethoxy-trans-feruloyltyramine (2), N-trans-feruloyltyramine (3), N-trans-feruloyl-3-methoxytyramine (4), N-trans-p-coumaroyltyramine (5) aurantiamide (6) and ferulic acid methyl ester (7) were isolated from Portulaca oleracea L. Compounds 2 and 7 were isolated for the first time from this plant. Compound 1 was identified using spectroscopic methods including HR-ESI-TOF-MS, 1D-NMR, 2D-NMR. It was tested in a nitric oxide (NO) inhibition assay and was shown to inhibit NO production in RAW 264.7 cells induced by LPS. |
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| Keywords: | Portulaca oleracea L alkaloid nitric oxide (NO) |
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