Chemical and biological studies on Cichorium intybus L. |
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| Authors: | Dinara Satmbekova Radhakrishnan Srivedavyasasri Yerkebulan Orazbekov Roza Omarova Ubaidilla Datkhayev |
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| Institution: | 1. Department of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan;2. National Center for Natural Product Research, University of Mississippi, University, MS, USA;3. National Center for Natural Product Research, University of Mississippi, University, MS, USA |
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| Abstract: | Cichorium intybus L. (Asteraceae family) is a world-wide grown plant known as chicory. In traditional medicine, this plant is used as diuretic, anti-inflammatory, digestive, cardiotonic and liver tonic. Chromatographic purification of the supercritical fluid extract of aerial parts of C. intybus on silica gel column led to isolation of three compounds: new compound, 28β-hydroxytaraxasterol (I), and two known compounds usnic acid (II) and β-sitosterol (III). Purification of the ethanolic extract of aerial parts of this plant on silica gel column chromatography yielded four compounds: 1,3-dioleylglycerate (IV), sitoindoside II (V), 11β-13-dihydrolactucin (VI) and β-sitosterol-3-O-glucoside (VII). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding, as well as antibacterial, antifungal and antimalarial activities. Compound I showed moderate activity (60.5% displacement) towards CB1 receptor. |
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| Keywords: | Cichorium intybus isolation cannabinoid receptor opioid receptor |
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