Chemical constituents of the fermentative extracts of marine fungi Phoma sp. CZD-F11 and Aspergillus sp. CZD-F18 from Zhoushan Archipelago,China |
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| Authors: | Xiaomei Wu Zhe Chen |
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| Institution: | 1. Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan, China;2. Zhejiang Key Laboratory of Gastrointestinal Pathophysiology, Chinese Traditional Medicine Hospital of Zhejiang Province, Hangzhou, China |
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| Abstract: | A new diphenyl ether (1) as well as 20 other compounds were identified from the fermentative extracts of marine-derived fungi Phoma sp. CZD-F11 (Compounds 1–8) and Aspergillus sp. CZD-F18(Compounds 9–21). Their structures were elucidated on the basis of extensive spectroscopic analysis. The broth extracts of the fungi exhibited very good anticancer activity against H1975 cells with 5.62 and 25.8% viability at concentration of 10 μg/mL for Phoma sp. CZD-F11 and Aspergillus sp. CZD-F18, respectively. The inhibitory activity of all compounds against PC-3 cell lines, BRD4 and aromatase were evaluated. The results showed compound 7 exhibited moderate anticancer activity with 66.1% inhibition against PC-3 cell lines at the concentration of 10 μg/mL. Compound 7 and 8 exhibited favourable BRD4 inhibitory activity with 78.5 and 76.4% inhibition at the concentration of 10 μg/mL. |
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| Keywords: | Marine-derived fungi diphenyl ether anticancer BRD 4 aromatase activity |
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