Two new monoterpenoid indole alkaloids from Alstonia rostrata |
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| Authors: | Yu-Xi Yuan Feng Guo Hong-Ping He |
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| Affiliation: | 1. Yunnan University of Traditional Chinese Medicine, Kunming, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China |
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| Abstract: | Two new indole alkaloids, winphyllines A (1) and B (4), along with four known alkaloids, Nb-demethylechitamine (2), 17-O-acetylnorechitamine (3), 12-methoxyechitamidine (5), and N(4)-demethylastogustine (6), were isolated from the methanol extract of the twigs of Alstonia rostrata. The structures of 1 and 4 were elucidated by means of HRMS and NMR spectroscopic methods. The in vitro cytotoxic activity of the isolated alkaloids against several human cancer cell lines was evaluated. |
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| Keywords: | Alstonia rostrata Apocynaceae monoterpene indole alkaloid |
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