A novel Salvialactomine from the callus culture of Salvia santolinifolia Boiss |
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| Authors: | Tour Jan Raiha Qadri Beena Naqvi Achyut Adhikari Said Nadeem Akhtar Muhammad |
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| Affiliation: | 1. Department of Botany, University of Malakand, Dir Lower, Pakistantourjan.ptc@uom.edu.pk tour_jan@yahoo.com;3. Department of Botany, University of Karachi, Karachi, Pakistan;4. PCSIR Laboratories Complex, Ministry of Science and Technology, Karachi, Pakistan;5. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;6. Faculty of Sciences, Department of Chemistry, Mu?la S?tk? Ko?man Univesity, Mu?la, Turkey;7. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;8. Department of Chemistry, Islamia College University, Peshawar, Pakistan |
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| Abstract: | A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D–NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i.e. Hela (Cervical cancer cell) and PC-3 (Prostate cancer cells). IC50 was found as > 30 using Doxorobicin (0.912 ± 0.12 μmol L?1) as a standard. |
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| Keywords: | Secondary metabolites callus Salvia santolinifolia lamiaceae hela PC-3 Murashige & Skoog (MS) 1-napthalen acetic acid (NAA) 6-benzyladenine (BA) |
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