Screening of several biological activities induced by different sesquiterpene lactones isolated from Centaurea behen L. and Rhaponticum repens (L.) Hidalgo |
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| Authors: | Abolfazl Shakeri Elaheh Amini Javad Asili Milena Masullo Sonia Piacente |
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| Institution: | 1. Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran;3. Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Salerno, Italy |
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| Abstract: | This study aims to evaluate the in vitro cytotoxic, in vitro and in ovo anti-angiogenic effects and antimicrobial activity of sesquiterpene lactones (SLs) from two plants Centaurea behen and Rhaponticum repens (L.). Five SLs, including cynaropicrin (1), 4β,15-dehydro-3-dehydrosolstitialin A (2), aguerin B (3), janerin (4), cebellin E (5), and a flavone hispidulin (6) were isolated from C. behen (compounds 1–3) and R. repens (compounds 4–6). Cynaropicrin (1) and aguerin B (3) were characterised by strong cytotoxic activities against A2780 cells with IC50 values of 1.15 and 1.62 μg mL?1, respectively, comparable to that of doxorubicin (IC50 = 1.17 μg mL?1). The anti-angiogenic study showed the remarkable inhibitory effect of cynaropicrin (1) and aguerin B (3) on the proliferation and migration of HUVECs. In addition, cynaropycrin and aguerin B exhibited significant angio-inhibitory effects in CAM assay. These findings may be useful for the development of novel chemotherapeutic agents for the treatment of cancer. |
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| Keywords: | Asteraceae Centaurea sesquiterpene lactone cytotoxic anti-angiogenic |
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