Efficient method for the synthesis of 1,2,3-triazole functionalized isoxazolidine derivatives by 1,3-dipolar cycloaddition of nitrones with terminal olefins |
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Authors: | P Sambasiva Rao K Chinna Ashalu G Jitender Dev N Ravi Kumar P V S S Srinivas B V Thomas |
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Institution: | Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India |
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Abstract: | 1-Phenyl-1,2,3-triazole-4-carbaldehyde 1 was treated with different N-alkyl hydroxylamine hydrochlorides 2 using NaHCO3 to obtain 1,2,3-triazole substituted N-alkyl nitrones 3a–c. The nitrones 3a–c were further reacted with different substituted olefins and furnished 2-alkyl-3-(1-phenyl-1H-1,2,3-triazol-4-yl)-5-(substituted)isoxazolidine derivatives 4a–p in high yields via 1,3-dipolar cycloaddition reaction. |
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Keywords: | 1 3-Dipolar cycloaddition isoxazolidine nitrones olefins 1 2 3-triazole |
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