Efficient and mild Strecker-type reaction of nitrones catalyzed by MgI2 etherate |
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| Authors: | Zhili Chen Xinyu Zhou Xiaoqiang Xie |
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| Institution: | College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, P. R. China |
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| Abstract: | An efficient Strecker-type reaction of nitrones with trimethylsilyl cyanide (TMSCN) catalyzed by MgI2 etherate has been achieved in a short time under mild condition. The condensations of aromatic nitrones, heterocyclic nitrones, and aliphatic nitrones with TMSCN are performed in good to excellent yields. Further dehydration of α-cyanohydroxylamine smoothly produced the α-imine nitrile in good yields by hydrolysis with the treatment of 2.0?mol/L HCl in methanol. |
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| Keywords: | α-Cyanohydroxylamines" target="_blank">α-Cyanohydroxylamines MgI2 etherate nitrones Strecker-type reaction TMSCN |
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