Syntheses,crystal structures and biological activity of the dialkytin complexes based on 2-oxo-3-phenylpropionic acid salicyloylhydrazone |
| |
| Authors: | Yuxing Tan Zhijian Zhang Yuhuan Tan Daizhi Kuang Jiangxi Yu Xiaoming Zhu |
| |
| Institution: | 1. Key Laboratory of Functional Organometallic Materials, Hengyang Normal University, College of Hunan Province, Hengyang, China;2. College of Chemistry and Material Science, Hengyang Normal University, Hengyang, China;3. College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, China |
| |
| Abstract: | Three new dialkytin complexes, {o-OH–C6H4(O)C=N–N=C(CH2Ph)COO](n-Bu2Sn)}n (1), {o-OH–C6H4(O)C=N–N=C(CH2Ph)COO](MeOH)(p-MeC6H5CH2)2Sn}2 (2), and {o-OH–C6H4(O)C=N–N=C(CH2Ph)COO](EtOH)(C6H5CH2)2Sn}2 (3), were synthesized by reactions of 2-oxo-3-phenylpropionic acid salicyloylhydrazone with the corresponding diorganotin(IV) complex, respectively. All the complexes were characterized by IR, 1H, 13C, 119Sn NMR spectra, elemental analysis, X-ray single crystal diffraction and TGA. For in vitro antitumor activities, complexes were evaluated by the MTT assay against three human cancer cell lines (NCI-H460, HepG2 and MCF7) and human cell line (HL7702). The results showed that 1 may be a better potential candidate for further chemical optimization and cancer therapy than 2 and 3. The interactions between the complexes and calf thymus DNA were studied; the interaction of 1 with calf thymus DNA was intercalation, 2 and 3 were intercalation and electrostatic binding. |
| |
| Keywords: | Organotin hydrazone synthesis crystal structure biological activity |
|
|
