Polyethylene glycol-promoted synthesis of pyrimido[1,2-a]benzimidazole and pyrano[2,3-c]pyrazole derivatives in water |
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Authors: | Dattatray Survase Babasaheb Bandgar |
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Institution: | 1. Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College, Kolhapur, Maharashtra, India;2. School of Chemical Science, Solapur University, Solapur, Maharashtra, India |
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Abstract: | Synthesis of pyrimido1,2-a]benzimidazole and pyrano2,3-c]pyrazole derivatives were achieved using polyethylene glycol (PEG-400) as promoting reaction medium in water under catalyst-free conditions at reflux and room temperature, respectively. The structure of pyrimido1,2-a]benzimidazole was confirmed using 1H NMR, 13C NMR, DEPT, and HMBC experiments. The promising points for the present methodology are efficiency, generality, high yield, short reaction time, cleaner reaction profile, ease of product isolation, simplicity, potential of recycling reaction medium, and finally agreement with green chemistry protocols. |
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Keywords: | Catalyst-free synthesis pyrimido[1 2-a]benzimidazole PEG-Water pyrano[2 3-c]pyrazole |
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