L-Proline catalyzed three component synthesis of pyrano[2,3-c]pyrazole-5-carbonitrile derivatives and in vitro antimalarial evaluation |
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Authors: | Kailasam Saravana Mani Subramaniam Parameswaran Rajendran |
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Institution: | 1. Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, Indiachemsaran.mani@gmail.com;3. Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India |
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Abstract: | An efficient one-pot synthesis of 6-amino-4-(2-chloroquinolin-3-yl)-3-methyl-2, 4-dihydro-pyrano2,3-c]pyrazole-5-carbonitrile derivatives (4a–f)(5a–f) by three component reactions of 2-chloroquinolin-3-carbaldehyde derivatives, malanonitrile, and 3-methyl pyrazolin-5-one derivatives catalyzed by L-proline in ethanol medium under mild conditions is established. The synthesized compounds were evaluated for antimalarial activity and the LC50/LC90 values were described. Compounds 4d, 5d, and 5f exhibits good antimalarial activity when compared to other pyrano2,3-c]pyrazole scaffolds. |
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Keywords: | 2-Chloroquinolin-3-carbaldehyde 3-methyl-1H-pyrazol-5(4H)-one 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one antimalarial-activity ethanol L-proline" target="_blank">L-proline malononitrile pyrano[2 3-c]pyrazol-5-carbonitrile |
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