Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004 |
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| Authors: | Xiaoyan Pang Xiuping Lin Yongqi Tian Rui Liang Junfeng Wang Bin Yang |
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| Affiliation: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China;2. University of Chinese Academy of Sciences, Beijing, China;3. Drug Discovery Pipeline/Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China |
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| Abstract: | Three new polyketides named trichbenzoisochromen A (1), 5,7-dihydroxy-3-methyl -2-(2-oxopropyl)naphthalene-1,4-dione (2) and 7-acetyl-1,3,6-trihydroxyanthracene-9,10- dione (3) together with six known compounds (4–9) were isolated from a sponge-derived fungus Trichoderma sp. SCSIO41004. The structures of three new polyketides (1–3) were determined by the extensive spectroscopic analysis, including 1D, 2D NMR and HRESIMS data. The absolute configuration of compound 1 was confirmed by the specific optical rotation value and CD spectra analyses. Compound 4 exhibited significant inhibitory activity against EV71 with the IC50 value of 25.7 μM. |
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| Keywords: | Trichoderma sp. SCSIO41004 sponge-derived fungus antiviral |
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