One new cytochalasin metabolite isolated from a mangrove-derived fungus Daldinia eschscholtzii HJ001 |
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| Authors: | Lu-Jia Yang Hai-Xia Liao Meng Bai Guo-Lei Huang You-Ping Luo Yan-Yan Niu |
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| Institution: | 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, China;2. Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, The Ministry of Education of China, Ocean University of China, Qingdao, China;3. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China |
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| Abstract: | One new cytochalasin metabolite 11]-cytochalasa-5(6),13-diene-1,21-dione-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*) (1), together with three known compounds (2–4) were obtained from the EtOAc extract of the endophytic fungus Daldinia eschscholtzii HJ001 isolated from the mangrove Brguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 1 and 2 were evaluated for their antibacterial and cytotoxic activities. |
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| Keywords: | Mangrove endophytic fungus Daldinia eschscholtzii cytochalasin |
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