Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae) |
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| Authors: | Rebeca P. Medina Vagner M. de Moura Cleuza C. da Silva Cecília M. A. de Oliveira Lucilia Kato Armando M. Pomini |
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| Affiliation: | 1. Departamento de Química, Universidade Estadual de Maringá, Maringá, Paraná, Brazil;2. Instituto de Química, Universidade Federal de Goiás, Goiania, Brazil |
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| Abstract: | The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line. |
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| Keywords: | Ixora brevifolia Rubiaceae antiproliferative activity anti-inflammatory activity |
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