Synthesis of thienyl-substituted isochromene derivatives through gold-catalyzed tandem heteroarylation/cycloisomerization of ortho-alkynylbenzaldehydes with thiophenes |
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| Authors: | Hongbo Zhu Xin Meng Guang Chen Xuejun Sun |
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| Affiliation: | Shandong Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Shandong, China |
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| Abstract: | We describe herein a gold-catalyzed tandem heteroarylation/cycloisomerization reaction of ortho-alkynylbenzaldehydes with thiophenes. By this reaction, a variety of 1-(thiophen-2-yl)-1H-isochromene derivatives can be obtained in good yield. |
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| Keywords: | Alkynylbenzaldehyde gold catalysis heteroarylation isochromene thiophene |
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