Synthesis of new 1,2,3-triazole linked benzimidazole molecules as anti-proliferative agents |
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Authors: | Ishani I Sahay |
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Institution: | Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India |
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Abstract: | One pot click chemistry is used to link triazole and benzimidazole pharmacophore to get N-((1-((1H-benzod]imidazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)aniline and its derivatives. Flexible linkages in the form of –CH2–R or –O–R/–N–R were designed during synthesis. All the newly synthesized compounds were characterized by FT-IR and NMR spectroscopy as well as high-resolution mass spectrometry. Selected compounds were screened for in vitro anti-proliferative activity using National Cancer Institute (NCI)-60 human tumor cell line screening program. The most potent structure N-((1-((1H-benzod]imidazol-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-4-chloroaniline 7e showed 40% growth inhibition in renal cancer cell line (UO-31) at 10?µM concentration. |
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Keywords: | Anti-proliferative benzimidazole click reaction 1 2 3-triazole |
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