Unusual product from the acid-catalyzed one-pot,multicomponent reaction of thiocarbohydrazide,aldehydes, and phenacyl bromides |
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| Authors: | Mohanad Shkoor Ayahtallah Al-Abade Ibtesam Aleteiwib Mahmoud Al-Talib |
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| Affiliation: | 1. Department of Chemistry and Earth Sciences, Qatar University, Doha, Qatarmshkoor@qu.edu.qa;3. Department of Chemistry, Yarmouk University, Irbid, Jordan |
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| Abstract: | A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents of aromatic aldehydes, and one equivalent of phenacyl bromides afforded the five-membered thiazole ring. The reactions proceed with novel chemoselectivity. Similar reported protocols have always afforded 1,3,4-thiadiazines. |
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| Keywords: | Chemoselectivity hydrazones multicomponent reaction thiazole thiocarbohydrazide thiocarbohydrazone |
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